Alzheimer and Lewy body Pathology or Creutzfeldt-Jakob Disease
Objective: To describe the neuropathological findings of a patient clinically presenting with rapidly progressive nonspecific neurological symptoms suggestive of Creutzfeldt-Jakob disease.
Methods: Clinical description with laboratory analyses, repeated electroencephalogram, cerebral computed tomography, magnetic resonance imaging studies and details on neuropathological work-up.
Results: Neuropathological examination excluded Creutzfeldt-Jakob disease.By contrast other neurodegenerative changes combining Alzheimer-type pathology and Lewy body pathology were detected as the most likely substrate of neurological symptoms.Conclusion: Dementia with Lewy bodies should be included in the differential diagnosis in individuals presenting with rapidly progressive dementia.
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