CTLA-4 +49 and TNF--308 Gene Polymorphisms in Celiac Patients with Exocrine Pancreatic Insufficiency

Vanja Licul, Nada Starčević Čizmarević, Smiljana Ristić, Ivana Mikolašević, Brankica Sinčić Mijandrušić


Celiac disease (CD) is a life-long gluten sensitive autoimmune disease of the small intestine affecting genetically susceptible individuals. Human leukocyte antigen (HLA) genotype contributes to the genetic risk for CD, but “non-HLA” genes also play a role. Clinical presentation could be classical, but majority of patients present with non-classical, atypical signs and symptoms. Endocrine and/or exocrine pancreatic insufficiency (EXPI) is common in celiac patients. The aim of our study was to assess EXPI among our CD patients by measurement of faecal pancreatic elastase (FE1) and to find potential association of CTLA-4 +49 and TNF-a-308 gene polymorphism and EXPI. Eighty three patients entered the study. Tissue transglutaminase antibodies (anti-TTG), faecal elastase-1 (FE1) assays and genotyping for the CTLA-4 +49 AG and TNF-a308 were performed. Of 83 patients with CD EXPI had 13 (15,6%). There was no statistically significant difference in frequency of polymorphisms for both genes (CTL-4 +49 i TNF-a-308) in the group with and without EXPI. In conclusion, EXPI is common in symptomatic CD patients, but further genetic studies with larger number of patients are needed.        


celiac disease, exocrine pancreatic insufficiency, gene polymorphism

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