Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy

Nevenka Milicevic, Milanka Mrčela, Ivana Lukić, Sanja Mandić, Vesna Horvat, Josip Galić


The aim of the study was to clarify whether serum levels of proinflammatory cytokine interleukin-6 (IL-6) could be a useful marker in prostate diseases. Serum IL-6 was determined prior to prostate biopsy procedure in 82 patients with prostate adenocarcinoma (PCa), 25 patients with benign prostatic hyperplasia (BPH), 24 patients with high-grade prostatic intraepithelial neoplasia (PIN) and 17 patients with chronic prostatitis. Serum IL-6 levels were compared with total PSA (tPSA), free PSA (fPSA) and the free/total ratio (f/tPSA) serum levels. Statistically significant difference was not found in serum IL-6 levels among the four groups (p=0.088). However, the patients with poorly differentiated PCa with Gleason score (GS) 4+3=7 and >7 had significantly higher serum IL-6 levels than the patients with moderately differentiated PCa with GS 3+4=7 and <7 (p=0.007). The findings suggest that serum IL-6 level might be a potentially useful marker for poorly differentiated PCa.


interleukin-6, serum levels, prostate biopsy, prostate-specific antigen, Gleason score

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